What a Nephrologist Needs to Know About Acute Liver Failure.

Abstract

Although relatively rare in the United States, acute liver failure (ALF) is associated with very high rates of morbidity and mortality. A leading cause of morbidity and mortality is cerebral edema and intracranial hypertension. Hypothermia, osmotic diuretics, and hyperosmolar therapy are commonly used to manage these complications; however, when these are ineffective, renal replacement therapy may be needed for volume management. Acute kidney injury is a common complication of ALF and may arise from a number of etiologies, including hepatorenal syndrome and acute tubular necrosis. Acute kidney injury is most common in patients who develop ALF because of acetaminophen toxicity or ischemia. With regard to renal replacement therapy, we will review specific considerations relevant to the management of the patient with ALF.

• Authors: Thomas M Leventhal, Kathleen D Liu
• Journal: Advances in chronic kidney disease (Adv Chronic Kidney Dis) Vol. 22 Issue 5 Pg. 376-81 (Sep 2015) ISSN: 1548-5609 [Electronic] United States
• PMID: 26311599 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Topics

• Acute Kidney Injury (diagnosis, epidemiology, therapy)
• Clinical Competence
• Combined Modality Therapy
• Comorbidity
• Female
• Humans
• Liver Failure, Acute (diagnosis, epidemiology, therapy)
• Liver Transplantation (methods)
• Male
• Nephrology (methods)
• Physician's Role
• Practice Patterns, Physicians'
• Prognosis
• Renal Dialysis (methods)
• Risk Assessment
• Severity of Illness Index
• Survival Rate