Aspirin plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus.

Abstract

Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.

• Authors: Tiago Rafael Veloso, Frank Oechslin, Yok-Ai Que, Philippe Moreillon, José Manuel Entenza, Stefano Mancini
• Journal: Pathogens and disease (Pathog Dis) Vol. 73 Issue 8 Pg. ftv060 (Nov 2015) ISSN: 2049-632X [Electronic] United States
• PMID: 26310867 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © FEMS 2015. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Platelet Aggregation Inhibitors
• Ticlopidine
• Aspirin

Topics

• Animals
• Aspirin (administration & dosage)
• Disease Models, Animal
• Endocarditis, Bacterial (microbiology, prevention & control)
• Enterococcus faecalis (growth & development)
• Female
• Gram-Positive Bacterial Infections (microbiology, prevention & control)
• Platelet Aggregation Inhibitors (pharmacology)
• Rats, Wistar
• Streptococcus (growth & development)
• Ticlopidine (administration & dosage)
• Treatment Outcome