YKL-40/CHI3L1 drives inflammation on the road of tumor progression.

Inflammation plays a vital role at different stages of tumor progression. The development of tumors is affected by inflammatory mediators produced by the tumor and the host. YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases. With the use of chronic inflammatory disease systems, we describe the role of YKL-40/chitinase-3-like-1 protein in enhancing the inflammatory response and its implications in tumorigenesis. We also discuss how pre-existing inflammation enhances tumor growth and metastasis. In this mini-review, we highlight the effect of YKL-40/chitinase-3-like-1 protein-associated inflammation in promoting tumor progression.
AuthorsStephania Libreros, Vijaya Iragavarapu-Charyulu
JournalJournal of leukocyte biology (J Leukoc Biol) Vol. 98 Issue 6 Pg. 931-6 (Dec 2015) ISSN: 1938-3673 [Electronic] United States
PMID26310833 (Publication Type: Journal Article, Review)
Copyright© Society for Leukocyte Biology.

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