YKL-40/CHI3L1 drives inflammation on the road of tumor progression.

Abstract

Inflammation plays a vital role at different stages of tumor progression. The development of tumors is affected by inflammatory mediators produced by the tumor and the host. YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases. With the use of chronic inflammatory disease systems, we describe the role of YKL-40/chitinase-3-like-1 protein in enhancing the inflammatory response and its implications in tumorigenesis. We also discuss how pre-existing inflammation enhances tumor growth and metastasis. In this mini-review, we highlight the effect of YKL-40/chitinase-3-like-1 protein-associated inflammation in promoting tumor progression.

• Authors: Stephania Libreros, Vijaya Iragavarapu-Charyulu
• Journal: Journal of leukocyte biology (J Leukoc Biol) Vol. 98 Issue 6 Pg. 931-6 (Dec 2015) ISSN: 1938-3673 [Electronic] United States
• PMID: 26310833 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © Society for Leukocyte Biology.

Chemical References

• Adipokines
• CHI3L1 protein, human
• Chitinase-3-Like Protein 1
• Inflammation Mediators
• Lectins
• Neoplasm Proteins

Topics

• Adipokines (immunology)
• Animals
• Chitinase-3-Like Protein 1
• Humans
• Inflammation (immunology, pathology)
• Inflammation Mediators (immunology)
• Lectins (immunology)
• Neoplasm Metastasis
• Neoplasm Proteins (immunology)
• Neoplasms (immunology, pathology)