Reported studies were searched from online electronic databases of Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI). The odds ratios (
ORs) and corresponding 95% confidence intervals (CIs) were calculated to assess the association between
IL6 -174C/G polymorphism and fracture risk.
RESULTS: Six studies evaluated the association between
IL6 -174C/G polymorphism and fracture risk. A significant association was found between
IL6 -174C/G polymorphism and fracture risk (OR=1.25; 95% CI, 1.10-1.43; P=0.0008). In the subgroup analysis of gender, we found that women with
IL6 -174C/G polymorphism had an increased fracture risk (OR=1.25; 95% CI, 1.07-1.46; P=0.005). In the subgroup analysis of type of fracture, we found that
IL6 -174C/G polymorphism was significantly associated with
wrist fracture (OR=1.25; 95% CI, 1.07-1.47; P=0.006) and
osteoporotic fracture (OR=1.60; 95% CI, 1.12-2.28; P=0.009). However, no significant association was found between
IL6 -174C/G polymorphism and hip fracture (OR=1.05; 95% CI, 0.89-1.24; P=0.53) and
stress fracture (OR=1.25; 95% CI, 0.97-1.61; P=0.08).
CONCLUSION: