Near-Infrared-Activated Nanocalorifiers in Microcapsules: Vapor Bubble Generation for In Vivo Enhanced Cancer Therapy.

Abstract

Photothermal therapy based on gold nanostructures has been widely investigated as a state-of-the-art noninvasive therapy approach. Because single nanoparticles cannot harvest sufficient energy, self-assemblies of small plasmonic particles into large aggregates are required for enhanced photothermal performance. Self-assembled gold nanorods in lipid bilayer-modified microcapsules are shown to localize at tumor sites, generate vapor bubbles under near-infrared light exposure, and subsequently damage tumor tissues. The polyelectrolyte multilayer enables dense packing of gold nanorods during the assembly process, which leads to the formation of vapor bubbles around the excited capsules. The resulting vapor bubbles achieve a high efficiency of suppressing tumor growth compared to single gold nanorods. In vivo experiments demonstrated the ability of soft-polymer multilayer microcapsules to cross the biological barriers of the body and localize at target tissues.

• Authors: Jingxin Shao, Mingjun Xuan, Luru Dai, Tieyan Si, Junbai Li, Qiang He
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 54 Issue 43 Pg. 12782-7 (Oct 19 2015) ISSN: 1521-3773 [Electronic] Germany
• PMID: 26306782 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Capsules
• Gold

Topics

• Animals
• Capsules
• Gold (chemistry, therapeutic use)
• Humans
• Hyperthermia, Induced (methods)
• Infrared Rays
• MCF-7 Cells
• Mice
• Models, Molecular
• Nanotubes (chemistry, ultrastructure)
• Neoplasms (pathology, therapy)
• Phototherapy (methods)
• Volatilization