The
drug-loaded composite electrospun nanofiber has attracted more attention in biomedical field, especially in
cancer therapy. In this study, a composite nanofiber was fabricated by electrospinning for
cancer treatment. Firstly, the
carbon nanotubes (CNTs) were selected as carriers to load the anticancer
drug-
doxorubicin (DOX) hydrochloride. Secondly, the DOX-loaded CNTs (DOX@CNTs) were incorporated into the
poly(lactic-co-glycolic acid) (PLGA) nanofibers via electrospinning. Finally, a new
drug-loaded nanofibrous scaffold (PLGA/DOX@CNTs) was formed. The properties of the prepared composite nanofibrous
mats were characterized by various techniques. The release profiles of the different DOX-loaded nanofibers were measured, and the in vitro antitumor efficacy against HeLa cells was also evaluated. The results showed that DOX-loaded CNTs can be readily incorporated into the nanofibers with relatively uniform distribution within the nanofibers. More importantly, the
drug from the composite nanofibers can be released in a sustained and prolonged manner, and thereby, a significant antitumor efficacy in vitro is obtained. Thus, the prepared composite nanofibrous
mats are a promising alternative for
cancer treatment.