Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.

Abstract

A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.

• Authors: Mary M Nguyen, Andrea S Carlini, Miao-Ping Chien, Sonya Sonnenberg, Colin Luo, Rebecca L Braden, Kent G Osborn, Yiwen Li, Nathan C Gianneschi, Karen L Christman
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 27 Issue 37 Pg. 5547-52 (Oct 07 2015) ISSN: 1521-4095 [Electronic] Germany
• PMID: 26305446 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Drug Carriers
• Micelles
• Polymers
• Matrix Metalloproteinase 2
• Mmp2 protein, rat
• Matrix Metalloproteinase 9
• Mmp9 protein, rat

Topics

• Animals
• Disease Models, Animal
• Drug Carriers (chemistry)
• Drug Delivery Systems (methods)
• Dynamic Light Scattering
• Fluorescence
• Heart (drug effects)
• Hydrophobic and Hydrophilic Interactions
• Injections, Intravenous
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Micelles
• Myocardial Infarction (drug therapy, enzymology)
• Myocardium (enzymology)
• Nanoparticles (chemistry)
• Polymers (chemistry)
• Rats
• Time Factors