HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET.

Abstract

The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates expression of viral and cellular genes and it modulates several cellular pathways leading to HIV-1 infection spreading and immune dysregulation. So far, Tat protein and the cellular pathways targeted by Tat may represent potential targets for new anti-HIV therapeutic approaches and vaccine development against AIDS.

• Authors: Chiara Chiozzini, Elena Toschi
• Journal: Current drug targets (Curr Drug Targets) Vol. 17 Issue 1 Pg. 33-45 ( 2016) ISSN: 1873-5592 [Electronic] United Arab Emirates
• PMID: 26302810 (Publication Type: Journal Article, Review)

Chemical References

• Anti-HIV Agents
• Peptide Fragments
• Viral Regulatory and Accessory Proteins
• tat Gene Products, Human Immunodeficiency Virus
• tat peptide (47-58), Human immunodeficiency virus 1

Topics

• Anti-HIV Agents (pharmacology)
• Drug Discovery
• HIV Infections (drug therapy, immunology, virology)
• HIV-1 (drug effects, pathogenicity, physiology)
• Humans
• Peptide Fragments (metabolism)
• Viral Regulatory and Accessory Proteins (metabolism)
• tat Gene Products, Human Immunodeficiency Virus (metabolism)