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Imaging biomarkers in tauopathies.

Abstract
Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid cognitive dysfunction and neuron loss. Selective PET ligands including [18F]THK5117, [18F]THK5351, [18F]AV1451 (T807) and [11C]PBB3 now provide in vivo imaging information about the timing and distribution of tau in the early phases of neurodegenerative diseases. They are potential imaging biomarkers for both supporting diagnosis and tracking disease progression. Here, we discuss the challenges posed in developing selective tau ligands as biomarkers, their state of development and the new clinical information that has been revealed.
AuthorsMelanie Dani, Paul Edison, David J Brooks
JournalParkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 22 Suppl 1 Pg. S26-8 (Jan 2016) ISSN: 1873-5126 [Electronic] England
PMID26299160 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Biomarkers
  • tau Proteins
Topics
  • Alzheimer Disease (diagnosis, metabolism)
  • Animals
  • Biomarkers (metabolism)
  • Brain (metabolism, pathology)
  • Humans
  • Molecular Imaging (trends)
  • Neurofibrillary Tangles (metabolism, pathology)
  • Positron-Emission Tomography (methods)
  • Supranuclear Palsy, Progressive (diagnosis, metabolism)
  • Tauopathies (diagnosis, metabolism)
  • tau Proteins (metabolism)

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