HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Multiple primary melanomas among 16,570 patients with melanoma diagnosed at Kaiser Permanente Northern California, 1996 to 2011.

AbstractBACKGROUND:
Published rates of cutaneous multiple primary melanoma (MPM) vary widely.
OBJECTIVE:
We examined incidence of and risk factors associated with MPMs among Kaiser Permanente Northern California members.
METHODS:
We estimated MPM incidence among 16,570 patients with melanoma from 1996 through 2011. We compared characteristics between patients with MPMs and single primary melanomas and estimated crude and adjusted hazard ratios of MPMs using Cox models.
RESULTS:
In all, 15,448 patients had a single melanoma and 1122 had MPMs. Patients with MPMs were older and more often male, non-Hispanic white, and partnered. Subsequent primary melanomas were diagnosed after a mean of 3.83 (SD 3.61, median 2.82) years and were more likely in situ and thinner than initial tumors. The risk of a subsequent melanoma decreased from 2% in the first year after diagnosis to a stable approximately 1% rate through 15 years of follow-up.
LIMITATIONS:
We lacked data on some known melanoma risk factors and had small numbers of non-white patients and certain tumor subtypes.
CONCLUSIONS:
The risk of MPMs, although highest in the first year after diagnosis, remains stable thereafter. Those at highest risk of MPMs are older, male, white, and partnered. Clinicians should be aware of the rate of MPMs and recognize high-risk subgroups.
AuthorsMegan M Moore, Alan C Geller, E Margaret Warton, Joan Schwalbe, Maryam M Asgari
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 73 Issue 4 Pg. 630-6 (Oct 2015) ISSN: 1097-6787 [Electronic] United States
PMID26298295 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Topics
  • Adult
  • Age Distribution
  • Aged
  • California (epidemiology)
  • Cohort Studies
  • Databases, Factual
  • Disease-Free Survival
  • Female
  • Humans
  • Insurance Claim Review
  • Male
  • Melanoma (epidemiology, pathology)
  • Middle Aged
  • Neoplasms, Multiple Primary (epidemiology, pathology)
  • Neoplasms, Second Primary (epidemiology, pathology)
  • Prevalence
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Assessment
  • Sex Distribution
  • Skin Neoplasms (epidemiology, pathology)
  • Survival Analysis

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: