KU80, a key factor for non-homologous end-joining, retards geminivirus multiplication.

Abstract

KU80 is well-known as a key component of the non-homologous end-joining pathway used to repair DNA double-strand breaks. In addition, the KU80-containing DNA-dependent protein kinase complex in mammals can act as a cytoplasmic sensor for viral DNA to activate innate immune response. We have now, to our knowledge for the first time, demonstrated that the speed of a systemic infection with a plant DNA geminivirus in Arabidopsis thaliana is KU80-dependent. The early emergence of Euphorbia yellow mosaic virus DNA was significantly increased in ku80 knockout mutants compared with wild-type sibling controls. The possible impact of KU80 on geminivirus multiplication by generating non-productive viral DNAs or its role as a pattern-recognition receptor against DNA virus infection is discussed.

• Authors: Kathrin S Richter, Holger Jeske
• Journal: The Journal of general virology (J Gen Virol) Vol. 96 Issue 9 Pg. 2913-2918 (Sep 2015) ISSN: 1465-2099 [Electronic] England
• PMID: 26297035 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Arabidopsis Proteins
• DNA Helicases
• Ku80 protein, Arabidopsis

Topics

• Arabidopsis (genetics, metabolism, virology)
• Arabidopsis Proteins (genetics, metabolism)
• Cell Nucleus (genetics, metabolism, virology)
• DNA End-Joining Repair
• DNA Helicases (genetics, metabolism)
• Geminiviridae (genetics, physiology)
• Plant Diseases (genetics, virology)
• Virus Replication