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Targeting breast cancer with sugar-coated carbon nanotubes.

AbstractAIMS:
To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting.
MATERIALS & METHODS:
Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells in vitro and in vivo.
RESULTS & CONCLUSION:
Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation in vivo. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.
AuthorsCale D Fahrenholtz, Mallinath Hadimani, S Bruce King, Suzy V Torti, Ravi Singh
JournalNanomedicine (London, England) (Nanomedicine (Lond)) Vol. 10 Issue 16 Pg. 2481-97 ( 2015) ISSN: 1748-6963 [Electronic] England
PMID26296098 (Publication Type: Journal Article, Research Support, American Recovery and Reinvestment Act, Research Support, N.I.H., Extramural)
Chemical References
  • Carbohydrates
  • Nanotubes, Carbon
Topics
  • Animals
  • Carbohydrates (chemistry)
  • Cell Line, Tumor
  • Mammary Neoplasms, Experimental (metabolism, pathology)
  • Mice
  • Nanotubes, Carbon
  • Tissue Distribution

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