Abstract | AIMS: MATERIALS & METHODS: RESULTS & CONCLUSION: Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid- glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation in vivo. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.
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Authors | Cale D Fahrenholtz, Mallinath Hadimani, S Bruce King, Suzy V Torti, Ravi Singh |
Journal | Nanomedicine (London, England)
(Nanomedicine (Lond))
Vol. 10
Issue 16
Pg. 2481-97
( 2015)
ISSN: 1748-6963 [Electronic] England |
PMID | 26296098
(Publication Type: Journal Article, Research Support, American Recovery and Reinvestment Act, Research Support, N.I.H., Extramural)
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Chemical References |
- Carbohydrates
- Nanotubes, Carbon
|
Topics |
- Animals
- Carbohydrates
(chemistry)
- Cell Line, Tumor
- Mammary Neoplasms, Experimental
(metabolism, pathology)
- Mice
- Nanotubes, Carbon
- Tissue Distribution
|