[The pathogenesis of respiration disorders in acute ischemia of the lower extremities and their correction using hemosorption].

Abstract

The level of hormones, metabolites, toxins and biologically active substances that reflects the degree of endogenous intoxication increases drastically in acute ischemia and revascularization of the extremity and decreases upon hemosorption (HS). This can be accounted for by their adsorption on the sorbent. According to the data of electron microscopy this pathology is accompanied by morphological signs of the "shock lung". Upon HS dystrophic and destructive changes in lung capillaries and alveolar epithelium are minimum. It is believed that surfactant release from second type pneumocytes promotes to the extension of alveoli and decrease of atelectasis. The early application of HS is pathogenetically grounded.

• Authors: I N Zimon, N A Mavlianova, F V Leonov, B Z Kasymov
• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 1989 Nov-Dec Issue 6 Pg. 32-5 ISSN: 0201-7563 [Print] Russia (Federation)
• Vernacular Title: [K patogenezu dykhatel'nykh rasstroĭstv pri ostroĭ ishemii nizhnikh koneshnesteĭ i korrektsii ikh s pomoshch'iu gemosorbtsii.
• PMID: 2629538 (Publication Type: English Abstract, Journal Article)

Topics

• Acute Disease
• Animals
• Dogs
• Extremities (blood supply)
• Female
• Hemoperfusion
• Ischemia (complications, therapy)
• Male
• Respiration Disorders (etiology, therapy)