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Glioblastoma Multiforme and Lipid Nanocapsules: A Review.

Abstract
Epidemiological data on central nervous system disorders call for a focus on the major hindrance to brain drug delivery, blood-central nervous system barriers. Otherwise, there is little chance of improving the short-term survival of patients with diseases such as glioblastoma multiforme, which is one of the brain disorders associated with many years of life lost. Targetable nanocarriers for treating malignant gliomas are a unique way to overcome low chemotherapeutic levels at target sites devoid of systemic toxicity. This review describes the currently available targetable nanocarriers, focusing particularly on one of the newest nanocarriers, lipid nanocapsules. All of the strategies that are likely to be exploited by lipid nanocapsules to bypass blood-central nervous system barriers, including the most recent targeting approaches (mesenchymal cells), and novel administration routes (convection enhanced delivery) are discussed, together with their most remarkable achievements in glioma-implanted animal models. Although these systems are promising, much research remains to be done in this field.
AuthorsJuan Aparicio-Blanco, Ana-Isabel Torres-Suárez
JournalJournal of biomedical nanotechnology (J Biomed Nanotechnol) Vol. 11 Issue 8 Pg. 1283-311 (Aug 2015) ISSN: 1550-7033 [Print] United States
PMID26295134 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Lipids
  • Nanocapsules
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, chemistry)
  • Blood-Brain Barrier (chemistry)
  • Brain Neoplasms (chemistry, drug therapy)
  • Evidence-Based Medicine
  • Glioblastoma (chemistry, drug therapy)
  • Humans
  • Lipids (chemistry)
  • Nanocapsules (administration & dosage, chemistry, ultrastructure)

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