[COMPARATIVE CARDIOPROTECTIVE EFFICACY OF COENZYME Q10 AND MEXICOR IN EXPERIMENTAL MODEL OF MYOCARDIAL INFARCTION IN RATS].

Abstract

Cardioprotective efficacy of coenzyme Q10 (CoQ10, ubidecarenone) and mexicor were evaluated on the 21st day of experimental myocardial infarction in Wistar rats. CoQ10 or mexicor were injected in a dose of 30 mg/kg intravenously 10 min after coronary artery occlusion. The observed cardioprotective effects of ubidecarenone and mexicor were close. Both drugs equally increased the survival of rats, prevented the development of dilatation and hypertrophy of the left ventricle, and improved the pump cardiac function.

• Authors: E I Kalenikova, O V Tokareva, O U Kulyak, E A Gorodetskaya, O S Medvedev
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 78 Issue 6 Pg. 12-4 ( 2015) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 26292508 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cardiotonic Agents
• Pyridines
• Vitamins
• ethylmethylhydroxypyridine succinate
• Ubiquinone
• coenzyme Q10

Topics

• Animals
• Cardiotonic Agents (pharmacology)
• Disease Models, Animal
• Male
• Myocardial Infarction (drug therapy, pathology, physiopathology)
• Pyridines (pharmacology)
• Rats
• Rats, Wistar
• Ubiquinone (analogs & derivatives, pharmacology)
• Vitamins (pharmacology)