Suppressive Effect of Dietary Fucoidan on Proinflammatory Immune Response and MMP-1 Expression in UVB-Irradiated Mouse Skin.

Abstract

It is well known that ultraviolet B irradiation leads to dermal inflammation. In this study, we found that Mekabu fucoidan suppressed edema, decreased the thickness of the prickle cell layer, and decreased matrix metalloproteinase 1 in the skin of mice irradiated with ultraviolet B. Moreover, we found that the mean level of interferon gamma of Mekabu fucoidan-treated, ultraviolet B-irradiated mice (approximately 2.2 ng/mL) was not significantly different from that in normal mice (approximately 2.5 ng/mL). In contrast, a significant decrease in the mean level of interferon gamma (approximately 1.3 ng/mL) in ultraviolet B-irradiated control mice was observed compared with that in Mekabu fucoidan-treated, ultraviolet B-irradiated mice. The mean thickness of the prickle cell layer in the skin of Mekabu fucoidan-treated, ultraviolet B-irradiated mice was less than that in the ultraviolet B-irradiated control mice. Metalloproteinase 1 activity was significantly higher in the skin of ultraviolet B-irradiated mice than in the skin of untreated, nonirradiated normal mice. Metalloproteinase 1 in the skin of ultraviolet B-irradiated, Mekabu fucoidan- or L(+)-ascorbic acid (vitamin C)-treated mice was significantly lower than that in the ultraviolet B-irradiated control mice. Mitigation of the morphological changes in Mekabu fucoidan-treated mice was correlated with a decrease in metalloproteinase 1 levels. These data indicate that Mekabu fucoidan is an effective suppressor of inflammation in an ultraviolet B-irradiated mouse model.

• Authors: Hiroko Maruyama, Hidekazu Tamauchi, Fumitaka Kawakami, Keiko Yoshinaga, Takahisa Nakano
• Journal: Planta medica (Planta Med) Vol. 81 Issue 15 Pg. 1370-4 (Oct 2015) ISSN: 1439-0221 [Electronic] Germany
• PMID: 26287767 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Polysaccharides
• fucoidan
• Matrix Metalloproteinase 13
• Mmp13 protein, mouse
• Ascorbic Acid

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (isolation & purification, pharmacology)
• Ascorbic Acid (pharmacology)
• Dermatitis (prevention & control)
• Diet
• Immunity (drug effects)
• Immunosuppression Therapy
• Matrix Metalloproteinase 13 (biosynthesis)
• Mice
• Polysaccharides (pharmacology)
• Skin (drug effects, radiation effects)
• Ultraviolet Rays
• Undaria (chemistry)