Abstract |
The influence of hydrophobicity on the internalization of polymeric nanoparticles (NPs) remains poorly investigated. The hydrophobicity of poly(L-lactide) was increased by copolymerization with cell-membrane-lipid components, and this significantly enhanced the uptake of NPs up to 60% in the human cervical cancer cell line in comparison to unmodified poly(L-lactide) NPs.
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Authors | Mariam Samadi Moghaddam, Markus Heiny, V Prasad Shastri |
Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Vol. 51
Issue 78
Pg. 14605-8
(Oct 07 2015)
ISSN: 1364-548X [Electronic] England |
PMID | 26287526
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Membrane Lipids
- Polyesters
- Polymers
- Lactic Acid
- poly(lactide)
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Topics |
- Cell Membrane
(metabolism)
- Hydrophobic and Hydrophilic Interactions
- Lactic Acid
(chemistry)
- Membrane Lipids
(metabolism)
- Nanoparticles
- Polyesters
- Polymerization
- Polymers
(chemistry)
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