Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery.

Abstract

PEG-PCL-PEG (PECE) hydrogel for intracameral injection as a sustained delivery system can get a stable release of the medication and achieve an effective local concentration. The injectable PECE hydrogel is thermosensitive nano-material which is flowing sol at low temperature and can shift to nonflowing gel at body temperature. This study evaluated the intracameral injection of bevacizumab combined with a PECE hydrogel drug release system on postoperative scarring and bleb survival after experimental glaucoma filtration surgery. The best result was achieved in the bevacizumab loaded PECE hydrogels group, which presented the lowest IOP values after surgery. And the blebs were significantly more persistent in this group. Histology, Massion trichrome staining and immunohistochemistry further demonstrated that glaucoma filtration surgery in combination with bevacizumab loaded PECE hydrogel resulted in good bleb survival due to scar formation inhibition. In conclusions, this study demonstrated that bevacizumab-loaded PECE hydrogel for intracameral injection as a sustained delivery system provide a great opportunity to increase the therapeutic efficacy of glaucoma filtration surgery.

• Authors: Qian Han, Yuqi Wang, Xiabin Li, Ribo Peng, Ailing Li, Zhiyong Qian, Ling Yu
• Journal: Journal of materials science. Materials in medicine (J Mater Sci Mater Med) Vol. 26 Issue 8 Pg. 225 (Aug 2015) ISSN: 1573-4838 [Electronic] United States
• PMID: 26286760 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Actins
• Angiogenesis Inhibitors
• Hydrogels
• Polyesters
• Vascular Endothelial Growth Factor A
• poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol)
• Bevacizumab
• Polyethylene Glycols

Topics

• Actins (metabolism)
• Angiogenesis Inhibitors (administration & dosage)
• Animals
• Bevacizumab (administration & dosage)
• Cicatrix (prevention & control)
• Disease Models, Animal
• Drug Delivery Systems
• Filtering Surgery (adverse effects)
• Glaucoma (drug therapy, physiopathology, surgery)
• Hydrogels
• Intraocular Pressure (drug effects)
• Polyesters
• Polyethylene Glycols
• Postoperative Complications (prevention & control)
• Rabbits
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)