Abstract | PURPOSE OF REVIEW: The purpose of this article is to discuss recent advances in serological testing for sporadic inclusion body myositis (sIBM) and to provide a review of their diagnostic utility and disease-specificity of auto- antibodies in sIBM. RECENT FINDINGS: The identification, prevalence and diagnostic utility of a new auto-antibody targeting cytosolic 5'-nucleotidase 1A (cN-1A) in the serum of sIBM patients have recently been published. These studies have shown that anti-cN-1A auto- antibodies have diagnostic utility for differentiating sIBM from other forms of myositis and from other neuromuscular diseases. Anti-cN-1A-positive patient sera are directed to multiple epitopes of cN-1A and contain, in addition to IgG, IgA and IgM, anti-cN-1A auto- antibodies. Recent studies have also shown a relatively high prevalence of these auto- antibodies in sera form Sjögren's syndrome and systemic lupus erythematosus patients. SUMMARY: The recent discovery of auto- antibodies to cN-1A provides a serological tool to aid the differentiation between inflammatory myopathies and supports the idea that apart from degeneration, an adaptive immune response may also play a role in sIBM pathophysiology. Future research will need to focus on standardization of methods to detect these auto- antibodies in order to further explore their specificity and diagnostic utility for sIBM.
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Authors | Megan K Herbert, Ger J M Pruijn |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 27
Issue 6
Pg. 595-600
(Nov 2015)
ISSN: 1531-6963 [Electronic] United States |
PMID | 26285103
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Autoantibodies
- 5'-Nucleotidase
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Topics |
- 5'-Nucleotidase
(biosynthesis, blood)
- Autoantibodies
(blood)
- Humans
- Myositis, Inclusion Body
(blood, diagnosis, immunology)
- Sensitivity and Specificity
- Serologic Tests
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