Linked pyridinyl-thiadiazoles: Design and synthesis as potential candidate for treatment of XDR and MDR tuberculosis.

Abstract

Multi-drug resistant (MDR) and extremely drug resistant (XDR) Mycobacterium tuberculosis strains have turned tuberculosis (TB) as "on the verge of eradication" to "most life threatening" disease. Furthermore, synergy with HIV and other immunosuppressive disease have strengthened its prevalence. This research reports small molecule anti-infectives which are specifically potent against several strains and isolates of TB. The hit compound 7f has also proved to be active against almost 25 clinical isolates comparable to marketed anti-TB agents.

• Authors: Niranjan S Mahajan, S C Dhawale
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 102 Pg. 243-8 (Sep 18 2015) ISSN: 1768-3254 [Electronic] France
• PMID: 26280920 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antitubercular Agents
• Pyridines
• Thiadiazoles

Topics

• Antitubercular Agents (chemical synthesis, chemistry, pharmacology)
• Dose-Response Relationship, Drug
• Humans
• Microbial Sensitivity Tests
• Molecular Structure
• Mycobacterium tuberculosis (drug effects)
• Pyridines (chemical synthesis, chemistry, pharmacology)
• Structure-Activity Relationship
• Thiadiazoles (chemical synthesis, chemistry, pharmacology)
• Tuberculosis, Multidrug-Resistant (drug therapy)