Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: The mean age and PSA value of the entire cohort were 76.0±7.2 years and 158.8±237.9 ng/mL, respectively. The median follow-up duration was 13.4±6.7 months. There were no statistically significant differences in clinical characteristics between patients who received abiraterone acetate with ADT duration<35 months and those who received abiraterone acetate with ADT duration≥35 months. There were also no significant differences in terms of PSA progression-free survival, radiologic progression-free survival, and clinical progression-free survival between patients with ADT duration<35 months and those with ADT duration ≥35 months. CONCLUSIONS: Although this was a retrospective study with a small sample size, we did not observe any statistically significant differences in the clinical response to abiraterone acetate between mCRPC patients with long ADT duration and those with short ADT duration in terms of disease progression-free survival.
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Authors | Ki Bom Kim, Jung Ki Jo, Soyeon Ahn, Sangchul Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee |
Journal | Korean journal of urology
(Korean J Urol)
Vol. 56
Issue 8
Pg. 580-6
(Aug 2015)
ISSN: 2005-6745 [Electronic] Korea (South) |
PMID | 26279827
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgen Receptor Antagonists
- Antineoplastic Agents
- Taxoids
- Docetaxel
- KLK3 protein, human
- Kallikreins
- Prostate-Specific Antigen
- Abiraterone Acetate
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Topics |
- Abiraterone Acetate
(administration & dosage)
- Aged
- Aged, 80 and over
- Androgen Receptor Antagonists
(administration & dosage)
- Antineoplastic Agents
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Disease Progression
- Docetaxel
- Drug Administration Schedule
- Humans
- Kallikreins
(blood)
- Male
- Neoplasm Metastasis
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms, Castration-Resistant
(drug therapy)
- Retrospective Studies
- Taxoids
(administration & dosage)
- Treatment Outcome
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