Pandalisines A and B, novel indolizidine alkaloids from the leaves of Pandanus utilis.

Abstract

Two novel alkaloids named pandalisines A (1) and B (2), constituting a new class of C8-substituted indolizidine moiety, were isolated from the leaves of Pandanus utilis. The structures of these new compounds were established by their mass and spectroscopic data. The absolute configuration was determined by the comparison of experimental CD and calculated ECD spectra. A plausible biosynthetic pathway for compounds 1 and 2 is advanced. The cytotoxic activities of the isolated alkaloids against A-549, Hep-G2, and MDA-MB-231 cancer cell lines were evaluated. The result showed that 1 and 2 are the first non-cytotoxic indolizidine alkaloids.

• Authors: Yuan-Bin Cheng, Yi-Hong Tsai, I-Wen Lo, Chen-Chang Haung, Yu-Chi Tsai, Ludger Beerhues, Mohamed El-Shazly, Ming-Feng Hou, Shyng-Shiou Yuan, Chin-Chung Wu, Fang-Rong Chang, Yang-Chang Wu
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 25 Issue 19 Pg. 4333-6 (Oct 01 2015) ISSN: 1464-3405 [Electronic] England
• PMID: 26277406 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Indolizidines
• pandalisine A
• pandalisine B

Topics

• Cell Line, Tumor
• Hep G2 Cells
• Humans
• Indolizidines (chemistry, isolation & purification)
• Molecular Structure
• Pandanaceae (chemistry)
• Plant Leaves (chemistry)