PACAP as a neuroprotective factor in ischemic neuronal injuries.

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

• Authors: Seiji Shioda, Tomoya Nakamachi
• Journal: Peptides (Peptides) Vol. 72 Pg. 202-7 (Oct 2015) ISSN: 1873-5169 [Electronic] United States
• PMID: 26275482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015. Published by Elsevier Inc.

Chemical References

• ADCYAP1 protein, human
• Neuroprotective Agents
• Pituitary Adenylate Cyclase-Activating Polypeptide
• Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide

Topics

• Animals
• Brain Ischemia (drug therapy, metabolism, pathology)
• Humans
• Neurons (metabolism, pathology)
• Neuroprotective Agents (metabolism, therapeutic use)
• Pituitary Adenylate Cyclase-Activating Polypeptide (metabolism, therapeutic use)
• Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide (metabolism)