Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1.

Abstract	MicroRNAs exert their functions by mainly regulating coding genes or long non-coding RNA expression. In the present study, we reported that hsa-miR-1 was down-regulated in breast cancer tissues. Restoration of miR-1 in breast cancer cells inhibited proliferation, motility and increased apoptosis in vitro. MiR-1 functioned as a tumor suppressor by targeting K-RAS and MALAT1. In addition, the effects of up-regulation of miR-1 were similar to that of silencing K-RAS and MALAT1 in breast cancer cells. In vivo study indicated that restoration of miR-1 inhibited tumor growth and metastasis. Patients with low miR-1 expression had poorer overall survival time than those with high miR-1 expression. Our findings emphasized the potential role of miR-1 as tumor suppressive miRNA in breast cancer.
Authors	Ruilei Liu, Jie Li, Yuanhui Lai, Yi Liao, Ruiming Liu, Wanshou Qiu
Journal	International journal of biological macromolecules (Int J Biol Macromol) Vol. 81 Pg. 491-7 (Nov 2015) ISSN: 1879-0003 [Electronic] Netherlands
PMID	26275461 (Publication Type: Journal Article)
Copyright	Copyright © 2015 Elsevier B.V. All rights reserved.
Chemical References	3' Untranslated Regions Biomarkers, Tumor KRAS protein, human MALAT1 long non-coding RNA, human MIRN1 microRNA, human MicroRNAs RNA, Long Noncoding RNA, Messenger Proto-Oncogene Proteins p21(ras)
Topics	3' Untranslated Regions Adult Aged Animals Apoptosis (genetics) Base Sequence Binding Sites Biomarkers, Tumor Breast Neoplasms (genetics, metabolism, pathology) Cell Line, Tumor Cell Movement (genetics) Cell Proliferation (genetics) Cell Transformation, Neoplastic (genetics) Disease Models, Animal Down-Regulation Ectopic Gene Expression Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans MicroRNAs (chemistry, genetics) Middle Aged Neoplasm Metastasis Neoplasm Staging Proto-Oncogene Proteins p21(ras) (chemistry, genetics) RNA Interference RNA, Long Noncoding (chemistry, genetics) RNA, Messenger (chemistry, genetics) Tumor Burden (genetics) Xenograft Model Antitumor Assays

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