HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

SAM68: Signal Transduction and RNA Metabolism in Human Cancer.

Abstract
Alterations in expression and/or activity of splicing factors as well as mutations in cis-acting splicing regulatory sequences contribute to cancer phenotypes. Genome-wide studies have revealed more than 15,000 tumor-associated splice variants derived from genes involved in almost every aspect of cancer cell biology, including proliferation, differentiation, cell cycle control, metabolism, apoptosis, motility, invasion, and angiogenesis. In the past decades, several RNA binding proteins (RBPs) have been implicated in tumorigenesis. SAM68 (SRC associated in mitosis of 68 kDa) belongs to the STAR (signal transduction and activation of RNA metabolism) family of RBPs. SAM68 is involved in several steps of mRNA metabolism, from transcription to alternative splicing and then to nuclear export. Moreover, SAM68 participates in signaling pathways associated with cell response to stimuli, cell cycle transitions, and viral infections. Recent evidence has linked this RBP to the onset and progression of different tumors, highlighting misregulation of SAM68-regulated splicing events as a key step in neoplastic transformation and tumor progression. Here we review recent studies on the role of SAM68 in splicing regulation and we discuss its contribution to aberrant pre-mRNA processing in cancer.
AuthorsPaola Frisone, Davide Pradella, Anna Di Matteo, Elisa Belloni, Claudia Ghigna, Maria Paola Paronetto
JournalBioMed research international (Biomed Res Int) Vol. 2015 Pg. 528954 ( 2015) ISSN: 2314-6141 [Electronic] United States
PMID26273626 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Adaptor Proteins, Signal Transducing
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • KHDRBS1 protein, human
  • RNA, Neoplasm
  • RNA-Binding Proteins
Topics
  • Adaptor Proteins, Signal Transducing (genetics, metabolism)
  • Biomarkers, Tumor (metabolism)
  • DNA-Binding Proteins (genetics, metabolism)
  • Humans
  • Neoplasms (physiopathology)
  • Polymorphism, Single Nucleotide (genetics)
  • RNA Splicing (genetics)
  • RNA, Neoplasm (genetics)
  • RNA-Binding Proteins (genetics, metabolism)
  • Signal Transduction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: