Abstract | BACKGROUND: Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population. Hence, the American Thyroid Association recommended screening thyroid function in obese pregnant women; however, the evidence for this is weak. For this purpose, our study investigated the relationship between high BMI and thyroid functions during early pregnancy in Liaoning province, an iodine-sufficient region of China. METHODS: RESULTS: BMI ≥ 25 kg/m(2) may act as an indicator of hypothyroxinemia and TPOAb positivity and BMI ≥ 30 kg/m(2) was associated with increases in the odds of hypothyroidism, hypothyroxinemia, and TPOAb positivity. The prevalence of isolated hypothyroxinemia increased among pregnant women with BMI > 24 kg/m(2). CONCLUSIONS: High BMI during early pregnancy may be an indicator of maternal thyroid dysfunction; for Asian women whose BMI > 24 kg/m(2) and who are within 8 weeks of pregnancy, thyroid functions should be assessed especially.
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Authors | Cheng Han, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Weiwei Zhou, Chenyang Li, Bin Xu, Lihua Bi, Tao Meng, Jianling Du, Shaowei Zhang, Zhengnan Gao, Xiaomei Zhang, Liu Yang, Chenling Fan, Weiping Teng, Zhongyan Shan |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2015
Pg. 351831
( 2015)
ISSN: 2314-6141 [Electronic] United States |
PMID | 26273610
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- anti-thyroglobulin
- thyroid microsomal antibodies
- Thyrotropin
- Iodine
- Iodide Peroxidase
- Thyroxine
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Topics |
- Autoantibodies
(blood)
- Body Mass Index
- China
- Female
- Humans
- Hypothyroidism
(blood, physiopathology)
- Iodide Peroxidase
(immunology)
- Iodine
(urine)
- Pregnancy
- Pregnancy Complications
(blood, diagnosis, physiopathology)
- Thyroid Function Tests
(methods)
- Thyroid Gland
(physiopathology)
- Thyrotropin
(blood)
- Thyroxine
(blood)
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