Thiol and thioether suppression of cis-platinum-induced nephrotoxicity in rats bearing the Walker 256 carcinosarcoma.

Abstract

An examination of eighteen thiols and thio ethers revealed that the simultaneous administration of several of these with cis-platinum (CDDP) at 7.5 mg/kg (25 mumols/kg) iv, as a single injection to rats bearing the Walker 256 carcinosarcoma led to significant reduction in the nephrotoxicity typically found with cis-platinum, and no apparent interference in its anti-neoplastic action towards this tumor. The thiols and thiol ethers were administered at a twenty-fold molar excess to the CDDP and were combined with the CDDP immediately prior to administration. The most effective compounds in suppression nephrotoxicity were D-, and L-methionine, methyl and ethyl L-methioninate, and N-acetyl-D, L-methionine.

• Authors: M M Jones, M A Basinger
• Journal: Anticancer research (Anticancer Res) 1989 Nov-Dec Vol. 9 Issue 6 Pg. 1937-41 ISSN: 0250-7005 [Print] Greece
• PMID: 2627140 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Ethers
• Sulfhydryl Compounds
• Cisplatin

Topics

• Animals
• Blood Urea Nitrogen
• Carcinoma 256, Walker (drug therapy)
• Cisplatin (therapeutic use, toxicity)
• Ethers
• Female
• Kidney (drug effects, pathology)
• Rats
• Rats, Inbred Strains
• Structure-Activity Relationship
• Sulfhydryl Compounds (therapeutic use)