Abstract | UNLABELLED: OBJECTIVES: This study investigated the mechanisms by which green tea attenuates the spontaneous onset of diabetes-induced periodontitis. METHODS: RESULTS: Diabetes resulted in significant bone loss and alterations in the number of cells that stained positive for inflammatory mediators. In the diabetic rats treated with green tea, we observed a decreased number of cells expressing RANKL and TNF-α compared with that observed in the diabetic rats treated with water. Additionally, green tea increased the numbers of cells that stained positive for OPG, RUNX-2 and IL-10 in the diabetic rats. CONCLUSION:
Green tea intake reduces expression of the pro-inflammatory cytokine TNF-α and the osteoclastogenic mediator RANKL to normal levels while increasing expression of the anti-inflammatory cytokine IL-10, the osteogenesis-related factor RUNX-2 and the anti-osteoclastogenic factor OPG. Therefore, green tea represents a potential therapeutic agent for the treatment of diabetes-related periodontal disease.
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Authors | Gabriela Gennaro, Marcela Claudino, Tania Mary Cestari, Daniele Ceolin, Patrícia Germino, Gustavo Pompermaier Garlet, Gerson Francisco de Assis |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 8
Pg. e0134784
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26270535
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Core Binding Factor Alpha 1 Subunit
- Cytokines
- Osteoprotegerin
- Runx2 protein, rat
- Tea
- Tnfrsf11b protein, rat
|
Topics |
- Animals
- Core Binding Factor Alpha 1 Subunit
(metabolism)
- Cytokines
(biosynthesis)
- Diabetes Mellitus, Type 1
(metabolism, pathology)
- Gene Expression Regulation
(drug effects)
- Male
- Osteoprotegerin
(metabolism)
- Periodontium
(metabolism, pathology)
- Rats
- Rats, Wistar
- Tea
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