Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1.

Abstract

2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when given to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.

• Authors: M Sakamoto, S Takayama, Y Hosoda
• Journal: Toxicologic pathology (Toxicol Pathol) Vol. 17 Issue 4 Pt 2 Pg. 754-8 ( 1989) ISSN: 0192-6233 [Print] United States
• PMID: 2626666 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Imidazoles
• 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole
• Alkaline Phosphatase

Topics

• Adipose Tissue (blood supply, enzymology, pathology)
• Alkaline Phosphatase (metabolism)
• Animals
• Body Weight (drug effects)
• Carcinogens
• Hemangioendothelioma (chemically induced, enzymology, pathology)
• Imidazoles (toxicity)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred Strains
• Regional Blood Flow