The adverse effect of
cypermethrin on the liver and kidney of weanling female rats and the protective effect of ethanolic extract of grape pomace were investigated in the present study. Weanling female rats were given
cypermethrin oral at a dose of 25 mg kg(-1)
body weight for 28 consecutive days. An additional two Cyp-trated groups received extract at a dose of 100 and 200 mg kg(-1)
body weight, respectively, throughout the experimental duration. Three groups more served as extract and control groups. Administration of Cyp resulted in a significant increase in
serum marker enzymes, for example,
aminotransferases (AST and ALT),
alkaline phosphatase (ALP), and gamma-glutamyl
transferase (GGT), and increases the level of
urea nitrogen and
creatinine. In contrast, Cyp caused significant decrease in levels of total
protein and
albumin and caused histopathological alterations in liver and kidneys of female rats. Coadministration of the extract to Cyp-treated female rats restored most of these biochemical parameters to within normal levels especially at high dose of extract. However, extract administration to Cyp-treated rats resulted in overall improvement in liver and kidney damage. This study demonstrated the adverse biohistological effects of Cyp on the liver and kidney of weanling female rats. The grape pomace extract administration prevented the toxic effect of Cyp on the above serum parameters. The present study concludes that grape pomace extract has significant
antioxidant and hepatorenal protective activity.