Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids.

Abstract

The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.

• Authors: Juan C Cedrón, Ángel G Ravelo, Leticia G León, José M Padrón, Ana Estévez-Braun
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 20 Issue 8 Pg. 13854-63 (Jul 30 2015) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 26263960 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents, Phytogenic

Topics

• Alkaloids (chemical synthesis, chemistry, pharmacology)
• Antineoplastic Agents, Phytogenic (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Humans
• Liliaceae (chemistry)
• Structure-Activity Relationship