[Effect of cefoperazone on the activity of selected parameters of cellular immunity in mice with experimental viral-bacterial infection].

Abstract

We applied mixed, viral-bacterial infections of mice (with influenza virus to the respiratory tract and Staphylococcus aureus) intereperitoneally. We used Sodium Cefoperazone subcutaneously in the dose of 30 mg/kg body weight 24, 48 and 72 hours after the infection. We evaluated phagocytic activity of the granulocytes isolated from animals and bactericidal activity of these cells expressed as their chemiluminescent activity. We studied it on the 3rd, 6th, 9th, and the 14th day after the infection. Phagocytic activity of cells taken from infected mice and treated with the preparation expressed as phagocytic index was the following: 0.38, 0.19; 0.88; 0.99 respectively. In the comparative studies, concerning the effect of preincubation of cells with antibiotic (at the concentration produced in blood serum by therapeutic doses) we found the increase in chemiluminescent process by 57% on the average. Analyzing the preliminary data form the experimental studies on the influence of Cefoperazone on mixed, viral-bacterial infections in mice we found the positive effect of the antibiotic evaluated in some immunological test. Intracellular killing of bacteria is stimulated. Preincubation of granulocytes with the antibiotic gives higher chemiluminescent activity of cells. However, chemotactic and phagocytic activity of cells are not changed.

• Authors: A Denys, M Kowalska, J Białek, T Szydłowska
• Journal: Polski tygodnik lekarski (Warsaw, Poland : 1960) (Pol Tyg Lek) Vol. 44 Issue 17 Pg. 387-9 (Apr 24 1989) ISSN: 0032-3756 [Print] Poland
• Vernacular Title: Wpływ cefaperazonu na aktywność wybranych parametrów odporności komókowej u myszy w doświadczalnym zakazeniu wirusowo-bakteryjnym.
• PMID: 2626359 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cefoperazone

Topics

• Animals
• Cefoperazone (therapeutic use)
• Drug Evaluation, Preclinical
• Influenza A virus
• Mice
• Neutrophils (drug effects, immunology)
• Orthomyxoviridae Infections (complications, drug therapy, immunology)
• Phagocytosis (drug effects)
• Staphylococcal Infections (complications, drug therapy, immunology)
• Staphylococcus aureus