Longitudinal study of serum antibody response to bovine corneal protein (BCP 54) in Behçet's disease.

Abstract

Serum samples from a patient diagnosed as having active Behçet's syndrome with iritis were evaluated by the enzyme-linked immunosorbent assay for antibodies against a purified bovine corneal protein, molecular weight 54,000 daltons (BCP 54). Significantly elevated antibody levels to BCP 54 were found in all serum samples collected over a 2-year period. Anti-BCP 54 antibody levels remained within a very narrow range, at least twofold higher than those of controls. In contrast, no antibody to retinal S antigen was detected. These results indicate the presence of specific anti-BCP 54 autoantibodies in sera from a Behçet's patient and suggest that autoantibodies may play a role in the etiopathogenesis of uveitis.

• Authors: A S Kong, W L Henley, M H Luntz
• Journal: Ophthalmic research (Ophthalmic Res) Vol. 21 Issue 6 Pg. 401-5 ( 1989) ISSN: 0030-3747 [Print] Switzerland
• PMID: 2626237 (Publication Type: Journal Article)

Chemical References

• Antibodies
• Antigens
• Arrestin
• Eye Proteins
• corneal protein 54, bovine
• Aldehyde Dehydrogenase

Topics

• Adolescent
• Aldehyde Dehydrogenase
• Antibodies (analysis, immunology)
• Antigens (immunology)
• Arrestin
• Behcet Syndrome (complications, immunology)
• Electrophoresis, Polyacrylamide Gel
• Enzyme-Linked Immunosorbent Assay
• Eye Proteins (immunology)
• Humans
• Iritis (complications, immunology)
• Longitudinal Studies