[Activity of topical flunoxaprofen in nonspecific vaginitis. Comparison with meclocycline sulfosalicylate].

Abstract

A trial was performed in 30 patients affected by non-specific vaginitis. The results show that the topical application (by vaginal washings) of flunoxaprofen produces a high therapeutic activity like that of meclocycline. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Therefore, the normalization of vaginal flora, with a remarkable increase of Döderlein bacillus, is exclusively due to local antiphlogistic activity of flunoxaprofen. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses.

• Authors: V Facchini, G Rispoli, F Dubini, P Bignami, C Sacchi
• Journal: Minerva ginecologica (Minerva Ginecol) Vol. 41 Issue 12 Pg. 609-14 (Dec 1989) ISSN: 0026-4784 [Print] Italy
• Vernacular Title: Attività di flunoxaprofene per uso topico nelle vaginiti aspecifiche. Confronto con meclociclina solfosalicilato.
• PMID: 2626206 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents, Local
• Anti-Inflammatory Agents, Non-Steroidal
• Benzoxazoles
• meclocycline
• flunoxaprofen
• Oxytetracycline

Topics

• Administration, Intravaginal
• Adolescent
• Adult
• Anti-Infective Agents, Local (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Benzoxazoles (administration & dosage, therapeutic use)
• Female
• Humans
• Oxytetracycline (analogs & derivatives, therapeutic use)
• Vaginitis (drug therapy, microbiology)