Aldosterone-to-
renin ratio (ARR) is a screening test for primary
aldosteronism, but it was impacted by a bunch of clinical covariates. The ARR is associated with
chronic kidney disease (CKD),
renal artery stenosis,
renin adenoma. This study aims to investigate relationship between ARR and primary
aldosteronism in CKD patients. A retrospective observational analysis involves 253 attendees from Urology Department of Chengdu Military General Hospital (China), comprising 146 patients with confirmed primary
aldosteronism, 56 patients with
essential hypertension, and 55 patients with
chronic kidney disease accounting for primary
kidney disease. Blood samples were drawn from patients with particular restriction for measuring serum
aldosteronism, plasma
renin activity, and serum
potassium. Receiver operating characteristic (ROC) curve of ARR was tested to establish cutoff values and to assess sensitivity and specificity. The results showed that LogARR values were significantly higher (P < 0.001), and PRA and serum
potassium values were significantly lower (P < 0.001) in primary
aldosteronism patients. By contrast, significantly higher serum
aldosterone and plasma
renin were observed in CKDs compared with the other two groups (P < 0.001). There was a significantly positive correlation between LogARR and serum
potassium (r = -0.0345, P < 0.001, R(2) = 0.093). The AUC for plasma
renin activity, logARR, and serum
aldosterone are 0.855, 0.84, and 0.501, respectively. ROC curve of logARR and plasma
renin activity in detection of primary
aldosteronism with higher sensitivity and specificity. In conclusion, this study indicated that the ARR act as the
biomarker for the primary
aldosteronism, and could distinguish from
chronic kidney disease.