Abstract |
The chemical structure of AMG-1 was isolated during our search for an effective compound to overcome the untoward effects of complete ischemia. The duration of gasping was prolonged significantly and dose-dependently in mice by the administration of AMG-1, the efficacy being 1000 times that seen with adenosine. However, AMG-1 had no effect on ischemia-induced passive avoidance impairment and histopathological degradation in CAl neurons in the hippocampus. The relationship between adenosine and its analogue and cerebral ischemia is discussed.
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Authors | H Araki, Y Karasawa, K Kawashima, M Hayashi, H Aihara, J H Huang |
Journal | Methods and findings in experimental and clinical pharmacology
(Methods Find Exp Clin Pharmacol)
Vol. 11
Issue 12
Pg. 731-6
(Dec 1989)
ISSN: 0379-0355 [Print] Spain |
PMID | 2626079
(Publication Type: Journal Article)
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Chemical References |
- 6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine
- Pentobarbital
- Adenosine
|
Topics |
- Adenosine
(analogs & derivatives, pharmacology)
- Animals
- Brain Ischemia
(pathology, physiopathology, prevention & control)
- Cell Survival
(drug effects)
- Gerbillinae
- Hippocampus
(cytology, drug effects)
- Male
- Mice
- Mice, Inbred ICR
- Motor Activity
(drug effects)
- Neurons
(drug effects)
- Pentobarbital
(pharmacology)
- Sleep
(drug effects)
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