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The adenosine analogue and cerebral protecting agent, AMG-1, has no effect on delayed neuronal death following ischemia.

Abstract
The chemical structure of AMG-1 was isolated during our search for an effective compound to overcome the untoward effects of complete ischemia. The duration of gasping was prolonged significantly and dose-dependently in mice by the administration of AMG-1, the efficacy being 1000 times that seen with adenosine. However, AMG-1 had no effect on ischemia-induced passive avoidance impairment and histopathological degradation in CAl neurons in the hippocampus. The relationship between adenosine and its analogue and cerebral ischemia is discussed.
AuthorsH Araki, Y Karasawa, K Kawashima, M Hayashi, H Aihara, J H Huang
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 11 Issue 12 Pg. 731-6 (Dec 1989) ISSN: 0379-0355 [Print] Spain
PMID2626079 (Publication Type: Journal Article)
Chemical References
  • 6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine
  • Pentobarbital
  • Adenosine
Topics
  • Adenosine (analogs & derivatives, pharmacology)
  • Animals
  • Brain Ischemia (pathology, physiopathology, prevention & control)
  • Cell Survival (drug effects)
  • Gerbillinae
  • Hippocampus (cytology, drug effects)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Motor Activity (drug effects)
  • Neurons (drug effects)
  • Pentobarbital (pharmacology)
  • Sleep (drug effects)

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