Abstract | INTRODUCTION: OBJECTIVE: The aim of this study was to investigate the frequency of splenomegaly related to clinical characteristics of sarcoidosis and to solve the dilemma--whether to introduce medicaments, and when to perform splenectomy. METHODS: The method of the study is a retrospective and prospective analysis of the patients'material. RESULTS: The study included 540 patients with sarcoidosis in a 20-year period. Of them, 26% had splenomegaly detected by computerized tomography screening. Splenomegaly was more frequently registered in the patients with a longer history of sarcoidosis (38%), as compared to those with a shorter history of the disease (23%) (p < 0.05). Splenomegaly was more frequently registered in the patients with other extrapulmonary lesions detected (33%) than in those who had no extrapulmonary manifestations of sarcoidosis (17%) (p < 0.01). Indications, possible benefits and complications of splenectomy were analysed in 11 sarcoidosis patients undergoing this intervention for various reasons, of which the follow-up period ranged from one to 20 years. CONCLUSION:
Splenomegaly was more frequent in chronic cases or in the patients with established sarcoid lesions of other extrapulmonary organs.The primary treatment of uncomplicated symptomatic splenic sarcoidosis includes medicamentous therapy. Occasionally, splenectomy is required. Prognostically, splenomegaly indicates an unfavorable course of the disease.
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Authors | Zora Pavlović-Popović, Bojan Zarić, Zdravko Kosjerina, Dragana Petrović |
Journal | Srpski arhiv za celokupno lekarstvo
(Srp Arh Celok Lek)
2015 May-Jun
Vol. 143
Issue 5-6
Pg. 279-83
ISSN: 0370-8179 [Print] Serbia |
PMID | 26259399
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Sarcoidosis, Pulmonary
(diagnosis, epidemiology, therapy)
- Splenomegaly
(diagnosis, epidemiology, therapy)
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