[A case of the benign adrenal adenoma with remarkably high concentrations of deoxycorticosterone and 11-deoxycortisol].

Abstract

The case was a 33-year-old woman with hypertension and hypokalemia, who presented depression of renin activity and the abnormal elevation of plasma deoxycorticosterone (DOC) and 11-deoxycortisol on laboratory tests. After admission, abdominal CT scan, 131I-adosterol scintigram and adrenal venogram revealed a tumor in the left adrenal, which histologically seemed to be benign. When the tumor was resected, blood pressure and all the biochemical data returned to normal range. DOC and 11-deoxycortisol levels in the tumor were abnormally elevated as compared with those in the normal adrenal tissue. These findings suggested that the abnormal elevation of hormone levels resulted from depression of 11 beta-hydroxylase. Though numerous adrenal tumors have been documented, we rarely encounter an apparently benign adrenal tumor that produces 2 kinds of hormones. This seemed to be the first case of benign adrenal tumor in which both DOC and 11-deoxycortisol were elevated.

• Authors: A Konta, T Osanai, Y Umemura, H Matsumura, T Kikuchi, H Eidoh, R Akiba, T Kanazawa, K Onodera, T Sobajima
• Journal: Nihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 31 Issue 11 Pg. 1223-7 (Nov 1989) ISSN: 0385-2385 [Print] Japan
• PMID: 2625746 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• 17-Hydroxycorticosteroids
• Desoxycorticosterone
• Cortodoxone

Topics

• 17-Hydroxycorticosteroids (blood)
• Adenoma (complications, diagnosis, pathology)
• Adrenal Gland Neoplasms (complications, diagnosis, pathology)
• Adult
• Cortodoxone (blood)
• Desoxycorticosterone (blood)
• Female
• Humans
• Hypertension (etiology)
• Hypokalemia (etiology)