Abstract |
Effect of aloctin A, glycoprotein isolated from leaves of Aloe arborescens MILL, on gastric secretion and on acute gastric lesions in rats were examined. Aloctin A given intravenously dose-dependently inhibited the volume of gastric juice, acid and pepsin output in pylorus-ligated rats. Aloctin A given intravenously significantly inhibited the development of Shay ulcers and indomethacin-induced gastric lesions in rats. It also inhibited water-immersion stress lesions induced in pylorus-ligated rats.
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Authors | H Saito, K Imanishi, S Okabe |
Journal | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
(Yakugaku Zasshi)
Vol. 109
Issue 5
Pg. 335-9
(May 1989)
ISSN: 0031-6903 [Print] Japan |
PMID | 2625663
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Anti-Ulcer Agents
- Lectins
- Plant Lectins
- aloctin A
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Anti-Ulcer Agents
- Dose-Response Relationship, Drug
- Gastric Mucosa
(metabolism)
- Lectins
(pharmacology)
- Male
- Plant Lectins
- Rats
- Rats, Inbred Strains
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