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Acute exposure to Buenos Aires air particles (UAP-BA) induces local and systemic inflammatory response in middle-aged mice: A time course study.

Abstract
Exposure to air particulate matter (PM) is associated with increased cardiovascular morbimortality. However, PM doesn't affect equally to all people, being the old cohort the most susceptible and studied. We hypothesized that another specific life phase, the middle-aged subpopulation, may be negatively affected. Therefore, the aim of this study was to analyze in vivo the acute biological impact of two environmental particles, Urban Air Particles from Buenos Aires and Residual Oil Fly Ash, on the cardiorespiratory system of middle-aged mice, evaluating oxidative metabolism and inflammation. Both PM provoked a local and systemic inflammatory response, leading to a reduced alveolar area in the lung, an epicard inflammation in the heart, an increment of IL-6, and a reduction on PON 1 activity in serum of middle-aged animals. The positive correlation of local parameters with systemic markers of oxidative stress and inflammation could be responsible for associations of cardiovascular morbimortality in this subpopulation.
AuthorsNadia S Orona, Sebastián A Ferraro, Francisco Astort, Celina Morales, Fernando Brites, Laura Boero, Gisela Tiscornia, Guillermo A Maglione, Paulo H N Saldiva, Sebastian Yakisich, Deborah R Tasat
JournalEnvironmental pollution (Barking, Essex : 1987) (Environ Pollut) Vol. 208 Issue Pt A Pg. 261-270 (Jan 2016) ISSN: 1873-6424 [Electronic] England
PMID26255684 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Air Pollutants
  • Biomarkers
  • Coal Ash
  • Interleukin-6
  • Particulate Matter
Topics
  • Air Pollutants (analysis, toxicity)
  • Animals
  • Argentina
  • Biomarkers (blood)
  • Bronchoalveolar Lavage Fluid (immunology)
  • Cardiovascular Diseases (chemically induced, immunology)
  • Coal Ash (analysis, toxicity)
  • Heart (drug effects)
  • Inflammation
  • Inhalation Exposure (adverse effects, analysis)
  • Interleukin-6 (blood, immunology)
  • Lung (drug effects, pathology)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Myocardium (immunology, pathology)
  • Oxidative Stress (drug effects, immunology)
  • Particulate Matter (analysis, toxicity)

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