HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Withaferin A attenuates lipopolysaccharide-induced acute lung injury in neonatal rats.

Abstract
Withaferin A (WFA) is an active compound from Withania somnifera and has been reported to exhibit a variety of pharmacological activities such as anti—inflammatory, immunomodulatory and anti—tumor properties. In the present study, we investigated the potential protective role of WFA on acute lung injury in neonatal rats induced by lipopolysaccharide (LPS). We found that WFA significantly attenuated the pathological changes of lungs induced by LPS injection. Administration with WFA obviously decreased pulmonary neutrophil infiltration accompanied with decreased MPO concentrations. WFA also reduced the expression of pro—inflammatory cytokines including MIP—2, TNF—α, IL—1β and IL—6. Meanwhile, the expression levels of anti—inflammatory mediators such as TGF—β1 and IL—10 were significantly increased following WFA administration. Moreover, WFA protected LPS—treated rats from oxidative damage via up—regulation of TBARS and H2O2 concentrations and down—regulation of ROS contents. Taken together, the present study demonstrated that WFA administration attenuated LPS—induced lung injury through inhibition of inflammatory responses and oxidative stress.
AuthorsS Gao, H Li, X-Q Zhou, J-B You, D-N Tu, G Xia, J-X Jiang, C Xin
JournalCellular and molecular biology (Noisy-le-Grand, France) (Cell Mol Biol (Noisy-le-grand)) Vol. 61 Issue 3 Pg. 102-6 (Jul 31 2015) ISSN: 1165-158X [Electronic] France
PMID26255139 (Publication Type: Journal Article)
Chemical References
  • Cytokines
  • Lipopolysaccharides
  • Reactive Oxygen Species
  • Withanolides
  • Hydrogen Peroxide
  • withaferin A
Topics
  • Acute Lung Injury (etiology, prevention & control)
  • Animals
  • Animals, Newborn
  • Cytokines (analysis, metabolism)
  • Disease Models, Animal
  • Down-Regulation (drug effects)
  • Enzyme-Linked Immunosorbent Assay
  • Hydrogen Peroxide (metabolism)
  • Lipopolysaccharides (toxicity)
  • Lung (drug effects, metabolism, pathology)
  • Male
  • Oxidative Stress (drug effects)
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species (metabolism)
  • Up-Regulation (drug effects)
  • Withania (chemistry, metabolism)
  • Withanolides (administration & dosage, chemistry, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: