Comparison of Porcine Small Intestinal Submucosa versus Polypropylene in Open Inguinal Hernia Repair: A Systematic Review and Meta-Analysis.

Abstract

BACKGROUND:

A systematic review and meta-analysis was performed in randomized controlled trials (RCTs) to compare porcine small intestinal submucosa (SIS) with polypropylene in open inguinal hernia repair.

METHOD:

Electronic databases MEDLINE, Embase, and the Cochrane Library were used to compare patient outcomes for the two groups via meta-analysis.

RESULT:

A total of 3 randomized controlled trials encompassing 200 patients were included in the meta-analysis. There was no significant difference in recurrence (P = 0.16), hematomas (P = 0.06), postoperative pain within 30 days (P = 0.45), or postoperative pain after 1 year (P = 0.12) between the 2 groups. The incidence of discomfort was significantly lower (P = 0.0006) in the SIS group. However, the SIS group experienced a significantly higher incidence of seroma (P = 0.03).

CONCLUSIONS:

Compared to polypropylene, using SIS in open inguinal hernia repair is associated with a lower incidence of discomfort and a higher incidence of seroma. However, well-designed larger RCT studies with a longer follow-up period are needed to confirm these findings.

• Authors: Xin Nie, Dongdong Xiao, Wenyue Wang, Zhicheng Song, Zhi Yang, Yuanwen Chen, Yan Gu
• Journal: PloS one (PLoS One) Vol. 10 Issue 8 Pg. e0135073 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26252895 (Publication Type: Comparative Study, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)

Chemical References

• Polypropylenes

Topics

• Animals
• Databases, Factual
• Hematoma (etiology)
• Herniorrhaphy (instrumentation, methods)
• Humans
• Intestine, Small (pathology)
• Odds Ratio
• Pain, Postoperative
• Polypropylenes
• Randomized Controlled Trials as Topic
• Recurrence
• Seroma (etiology)
• Surgical Mesh
• Swine
• Treatment Outcome