The purpose of this study was to evaluate the safety and therapeutic efficacy of computed tomography (CT)-guided I seed implant
brachytherapy in patients with painful metastatic bone lesions after failure of external beam
radiation therapy (EBRT).From August 2012 to July 2014, 26 patients with painful bone
metastases after failure of EBRT were treated with CT-guided I seed implant
brachytherapy. Patient
pain and
analgesic use were measured using the Brief
Pain Inventory before treatment, weekly for 4 weeks, and every 4 weeks thereafter for a total of 24 weeks.
Opioid analgesic medications and complications were monitored at the same follow-up intervals.Before I seed implantation, the mean score for worst
pain in a 24-hour period was 7.3 out of 10. Following treatment, at weeks 1, 4, 8, 12, and 24, worst
pain decreased to 5.0 (P < 0.0001), 3.0 (P < 0.0001), 2.8 (P < 0.0001), 2.6 (P < 0.0001), and 2.0 (P = 0.0001), respectively.
Opioid usage significantly decreased at weeks 4, 8, and 12. Overall response rates of osseous
metastases after I seed implantation at 1, 4, 8, 12, and 24 weeks were 58%, 79%, 81%, 82%, and 80%, respectively. Adverse events were seen in 4 patients, including Grade 1 myelosuppression and Grade 1 late skin toxicity.I seed
brachytherapy is a safe and effective treatment for patients with painful bone
metastases after failure of EBRT.