Abstract | UNLABELLED: METHODS: A cohort of patients (n=94), including those with an expert clinical diagnosis of logopenic (n=19), nonfluent (n=16), or semantic (n=13) variants of primary progressive aphasia, corticobasal syndrome (n=14), or Alzheimer disease (n=24), underwent 18F-FDG metabolic and 11C-labeled Pittsburgh compound B (11C-PiB) amyloid PET brain imaging. 18F-FDG PET scans interpreted with Neurostat and 3D-SSP displays were classified as revealing Alzheimer disease or "other" by interpreters who were unaware of the clinical assessments and 11C-PiB PET results. 11C-PiB PET imaging was considered to be the diagnostic reference standard, with a threshold standardized uptake value ratio of 1.5 being indicative of Alzheimer disease pathology. To address possible bias from subgroup selection for the Alzheimer disease binary classifier, we calculated both conventional and balanced accuracies. RESULTS: Diagnoses of Alzheimer disease based on 18F-FDG PET resulted in 84% accuracy (both conventional and balanced). In comparison, diagnoses based on clinical assessments resulted in 65% conventional accuracy and 67% balanced accuracy. CONCLUSION:
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Authors | Carl Taswell, Victor L Villemagne, Paul Yates, Hitoshi Shimada, Cristian E Leyton, Kirrie J Ballard, Olivier Piguet, James R Burrell, John R Hodges, Christopher C Rowe |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 56
Issue 10
Pg. 1547-53
(Oct 2015)
ISSN: 1535-5667 [Electronic] United States |
PMID | 26251415
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc. |
Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease
(diagnosis, diagnostic imaging)
- Aphasia, Primary Progressive
(diagnosis, diagnostic imaging)
- Brain
(diagnostic imaging)
- Dementia
(diagnosis, diagnostic imaging)
- Diagnosis, Differential
- Female
- Fluorodeoxyglucose F18
- Humans
- Male
- Middle Aged
- Positron-Emission Tomography
(methods)
- Predictive Value of Tests
- Radiopharmaceuticals
- Reproducibility of Results
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