Relation of Combined Non-High-Density Lipoprotein Cholesterol and Apolipoprotein B With Atherosclerosis in Adults With Type 1 Diabetes Mellitus.

Abstract

Apolipoprotein B (apoB) and non-high-density lipoprotein cholesterol (non-HDL-C) are cardiovascular disease risk markers, although data in adults with type 1 diabetes mellitus (DM) are limited. We hypothesized that elevated apoB and non-HDL-C would be associated with greater odds of coronary artery calcification progression (CACp), a measure of coronary atherosclerosis, than either category alone in adults with type 1 DM. We grouped subjects with type 1 DM (n = 652) into 4 groups: elevated apoB (≥90 mg/dl) and elevated non-HDL-C (≥130 mg/dl), elevated non-HDL-C alone, elevated apoB alone, and normal apoB and non-HDL-C. We used logistic regression to examine the associations between the groups and CACp for a period of 6 years. We performed sensitivity analyses with elevated apoB and non-HDL-C redefined as at or more than the cohort means (91.4 and 119.0 mg/dl, respectively). Subjects with elevated apoB and non-HDL-C had greater odds of CACp compared with those with normal apoB and non-HDL-C (odds ratio 1.90, 95% confidence interval 1.15 to 3.15) and compared with subjects with elevated apoB alone (odds ratio 2.86, 95% confidence interval 1.43 to 5.74) adjusting for age, gender, duration, hemoglobin A1c, and statins. Similar results were obtained with elevated apoB and non-HDL-C defined as at or more than the cohort means. In conclusion, elevated apoB and non-HDL-C carry a greater risk of atherosclerosis than elevated apoB in the absence of elevated non-HDL-C in adults with type 1 DM. These data suggest that apoB and non-HDL-C should be viewed as complementary rather than competitive indexes of cardiovascular disease risk in type 1 DM.

• Authors: Petter Bjornstad, Robert H Eckel, Laura Pyle, Marian Rewers, David M Maahs, Janet K Snell-Bergeon
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 116 Issue 7 Pg. 1057-62 (Oct 01 2015) ISSN: 1879-1913 [Electronic] United States
• PMID: 26251001 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Apolipoproteins B
• Biomarkers
• Cholesterol, HDL

Topics

• Adult
• Apolipoproteins B (blood)
• Atherosclerosis (blood, complications)
• Biomarkers (blood)
• Body Mass Index
• Calcinosis (diagnosis, epidemiology, etiology)
• Cholesterol, HDL (blood)
• Colorado (epidemiology)
• Coronary Artery Disease (blood, complications)
• Diabetes Mellitus, Type 1 (blood, complications)
• Female
• Follow-Up Studies
• Humans
• Incidence
• Male
• Middle Aged
• Risk Factors
• Time Factors
• Young Adult