Abstract | PROBLEM: Previous studies have shown that dydrogesterone, the orally administered progestogen, upregulates the production of Th2 cytokines and downregulates Th1 cytokine production. This study was designed to ascertain whether dihydrodydrogesterone (DHD), the major metabolite of dydrogesterone, is similarly capable of modulating cytokine production by peripheral blood mononuclear cells (PBMC) from women with a history of unexplained recurrent miscarriage. METHOD OF STUDY: RESULTS: CONCLUSION: Dihydrodydrogesterone retains the immunomodulatory effects of the progestogen dydrogesterone by bringing about a shift in cytokine production profiles that might be conducive to the success of pregnancy.
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Authors | Raj Raghupathy, Majedah Al-Azemi |
Journal | American journal of reproductive immunology (New York, N.Y. : 1989)
(Am J Reprod Immunol)
Vol. 74
Issue 5
Pg. 419-26
(Nov 2015)
ISSN: 1600-0897 [Electronic] Denmark |
PMID | 26250154
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Cytokines
- Hormone Antagonists
- Mifepristone
- Progesterone
- Dydrogesterone
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Topics |
- Abortion, Habitual
(metabolism)
- Cytokines
(metabolism)
- Dydrogesterone
(pharmacology)
- Female
- Hormone Antagonists
(pharmacology)
- Humans
- Leukocytes, Mononuclear
(drug effects, metabolism)
- Mifepristone
(pharmacology)
- Pregnancy
- Progesterone
(pharmacology)
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