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Synthesis of dual-functional targeting probes for cancer theranostics based on iron oxide nanoparticles coated by centipede-like polymer connected with pH-responsive anticancer drug.

Abstract
A tumor-targeted and pH-responsive drug release system based on superparamagnetic iron oxide nanoparticles (IONPs) coated by poly(ethylene glycol) (PEG) and dodecylamine (DDA)-modified polyitaconic acid (PIA) connecting with bortezomib (BTZ) (PIA-PEG-DDA-BTZ@IOs) has been constructed and characterized. The anticancer drug BTZ was first conjugated using dopamine as the linker via catechol borate ester bond, which is acid cleavable and used as an ideal pH-responsive drug release system. The IONPs were then coated by PIA-PEG-DDA-BTZ to form micelles with good biocompatibility. The conjugates were further designed to target liver cancer cells overexpressing vascular endothelial growth factor (VEGF) by the targeting molecule anti-vascular endothelial growth factor (anti-VEGF). The magnetic resonance imaging showed that the targeting capability of IONPs-anti-VEGF conjugates to Hep G2 cells was more significant than that of non-anti-VEGF IONPs. From the above, this kind of novel dual-functional targeting probe could provide a new idea for the diagnosis and treatment of cancer.
AuthorsHaochen Zhao, Zhiping Li, Bohan Yang, Jingyuan Wang, Yapeng Li
JournalJournal of biomaterials science. Polymer edition (J Biomater Sci Polym Ed) Vol. 26 Issue 16 Pg. 1178-89 ( 2015) ISSN: 1568-5624 [Electronic] England
PMID26249213 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amines
  • Antibodies, Immobilized
  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Magnetite Nanoparticles
  • Recombinant Proteins
  • Succinates
  • Vascular Endothelial Growth Factor A
  • Polyethylene Glycols
  • Bortezomib
  • itaconic acid
  • dodecylamine
Topics
  • Absorption, Physiological
  • Amines (chemistry)
  • Animals
  • Antibodies, Immobilized (administration & dosage, chemistry, metabolism, pharmacology)
  • Antineoplastic Agents (administration & dosage, metabolism, pharmacokinetics, pharmacology)
  • Bortezomib (administration & dosage, metabolism, pharmacokinetics, pharmacology)
  • Cell Survival (drug effects)
  • Delayed-Action Preparations (administration & dosage, metabolism, pharmacokinetics, pharmacology)
  • Drug Delivery Systems
  • Drug Liberation
  • Hep G2 Cells
  • Hepatocytes (drug effects, metabolism, pathology)
  • Humans
  • Hydrogen-Ion Concentration
  • Liver Neoplasms, Experimental (drug therapy, metabolism, pathology)
  • Magnetite Nanoparticles (chemistry, ultrastructure)
  • Male
  • Mice, Inbred ICR
  • Polyethylene Glycols (chemistry)
  • Recombinant Proteins (chemistry, metabolism)
  • Succinates (chemistry)
  • Surface Properties
  • Theranostic Nanomedicine (methods)
  • Tissue Distribution
  • Vascular Endothelial Growth Factor A (antagonists & inhibitors, genetics, metabolism)

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