A retrospective, nonrandomized, interventional case series of 8100 patients with
uveal melanoma were evaluated for
melanoma-related
metastasis based on patient race. The patient race was Caucasian (n=7918, 98%), Hispanic (n=105, 1%), Asian (n=44, <1%), or African American (n=33, <1%). On the basis of race (Caucasian, Hispanic, Asian, and African American), significant differences were noted in mean age at presentation (58, 48, 44, and 52 years; P<0.001), distance of posterior
tumor margin to foveola (5, 5, 6, and 4 mm; P<0.001), distance of posterior
tumor margin to optic disc (5, 5, 6, and 4 mm) (P<0.001),
tumor base (11, 12, 12, and 13 mm; P<0.001),
tumor thickness (5.4, 7.1, 6.5, and 7.5 mm; P<0.001), intraocular
hemorrhage (10, 14, 11, and 24%; P=0.02), and
rupture of Bruch's membrane (20, 27, 39, and 36%; P=0.001). On the basis of multivariate analysis, the rate of
metastasis increased with increasing age (P<0.001), ciliary body location (P<0.001), increasing
tumor base (P<0.001), increasing
tumor thickness (P<0.001), pigmented
tumor (P=0.001), subretinal fluid (P=0.001), intraocular
hemorrhage (P=0.045), and extraocular extension (P=0.036). Kaplan-Meier estimates of
metastasis at 3, 5, and 10 were 8, 15, and 25% in Caucasians; 13, 13, and 13% in Hispanics; 4, 4, and 36% in Asians; and 8, 8, and 8% in African Americans. Compared with Caucasians, despite relative risk for
metastasis of 0.31 for African Americans, 0.73 for Hispanics, and 1.42 for Asians, there was no statistical difference in
metastasis, or death from
uveal melanoma based on race. In summary,
uveal melanoma showed similar prognosis for all races.