Abstract | AIMS:
Tumor-specific targeted imaging is rapidly evolving in cancer diagnosis. The folate receptor alpha (FR-α) has already been identified as a suitable target for cancer therapy and imaging. FR-α is present on ~40% of human cancers. FR-β is known to be expressed on several hematologic malignancies and on activated macrophages, but little is known about FR-β expression in solid tumors. Additional or simultaneous expression of FR-β could help extend the indications for folate-based drugs and imaging agents. In this study, the expression pattern of FR-β is evaluated in ovarian, breast and colorectal cancer. METHODS: RESULTS: FR-β expression was seen in 21% of ovarian cancer samples, 9% of breast cancer samples, and 55% of colorectal cancer samples. Expression was weak or moderate. Of the diverticulitis samples, 80% were positive for FR-β expression in macrophages. FR-β status neither correlated to known disease-related variables, nor showed association with overall survival and progression free survival in ovarian and breast cancer. In breast cancer, negative axillary status was significantly correlated to FR-β expression (p=0.022). CONCLUSIONS: FR-β expression was low or absent in the majority of ovarian, breast and colorectal tumor samples. From the present study we conclude that the low FR-β expression in ovarian and breast tumor tissue indicates limited practical use of this receptor in diagnostic imaging and therapeutic purposes. Due to weak expression, FR-β is not regarded as a suitable target in colorectal cancer.
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Authors | Esther de Boer, Lucia M A Crane, Marleen van Oosten, Bert van der Vegt, Tineke van der Sluis, Paulien Kooijman, Philip S Low, Ate G J van der Zee, Henriette J G Arts, Gooitzen M van Dam, Joost Bart |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 8
Pg. e0135012
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26248049
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
(diagnosis, genetics, mortality, pathology)
- Colorectal Neoplasms
(diagnosis, genetics, mortality, pathology)
- Diverticulitis, Colonic
(diagnosis, genetics, metabolism, pathology)
- Female
- Folate Receptor 2
(genetics, metabolism)
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Macrophages
(metabolism, pathology)
- Middle Aged
- Optical Imaging
- Ovarian Neoplasms
(diagnosis, genetics, mortality, pathology)
- Survival Analysis
- Tissue Array Analysis
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