Abstract |
The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I ( CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P ≥ .72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.
|
Authors | Zohar Yehoshua, Carlos Alexandre de Amorim Garcia Filho, Renata Portella Nunes, Giovanni Gregori, Fernando M Penha, Andrew A Moshfeghi, Hongrong Luo, Zhang Kang, SriniVas Sadda, William Feuer, Philip J Rosenfeld |
Journal | Ophthalmic surgery, lasers & imaging retina
(Ophthalmic Surg Lasers Imaging Retina)
2015 Jul-Aug
Vol. 46
Issue 7
Pg. 772-4
ISSN: 2325-8179 [Electronic] United States |
PMID | 26247461
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2015, SLACK Incorporated. |
Chemical References |
- CFH protein, human
- Complement C2
- Complement C3
- Complement Factor H
- CFI protein, human
- Complement Factor I
|
Topics |
- Complement C2
- Complement C3
- Complement Factor H
(genetics)
- Complement Factor I
(genetics)
- Fluorescein Angiography
- Genotyping Techniques
- Geographic Atrophy
(genetics, pathology)
- Humans
- Polymorphism, Single Nucleotide
- Tomography, Optical Coherence
|