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Association Between Growth of Geographic Atrophy and the Complement Factor I Locus.

Abstract
The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P ≥ .72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.
AuthorsZohar Yehoshua, Carlos Alexandre de Amorim Garcia Filho, Renata Portella Nunes, Giovanni Gregori, Fernando M Penha, Andrew A Moshfeghi, Hongrong Luo, Zhang Kang, SriniVas Sadda, William Feuer, Philip J Rosenfeld
JournalOphthalmic surgery, lasers & imaging retina (Ophthalmic Surg Lasers Imaging Retina) 2015 Jul-Aug Vol. 46 Issue 7 Pg. 772-4 ISSN: 2325-8179 [Electronic] United States
PMID26247461 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2015, SLACK Incorporated.
Chemical References
  • CFH protein, human
  • Complement C2
  • Complement C3
  • Complement Factor H
  • CFI protein, human
  • Complement Factor I
Topics
  • Complement C2
  • Complement C3
  • Complement Factor H (genetics)
  • Complement Factor I (genetics)
  • Fluorescein Angiography
  • Genotyping Techniques
  • Geographic Atrophy (genetics, pathology)
  • Humans
  • Polymorphism, Single Nucleotide
  • Tomography, Optical Coherence

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